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    Determining Fetal Manganese Exposure from Mantle Dentine of Deciduous Teeth
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    † Environmental and Occupational Medicine and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States
    ‡ Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, United States
    § Institute of Dental Research, and Oral Pathology and Oral Medicine, Faculty of Dentistry, University of Sydney, Sydney, NSW, Australia
    ∥ Elemental Bio-Imaging Facility, University of Technology, Sydney, Sydney, NSW, Australia
    ⊥ Center for Environmental Research and Children’s Health (CERCH), School of Public Health, University of California, Berkeley, California, United States
    *Phone: 617 384 8876; fax: 617 384 8994; e-mail: [email protected]
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    Environmental Science & Technology

    Cite this: Environ. Sci. Technol. 2012, 46, 9, 5118–5125
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    https://doi.org/10.1021/es203569f
    Published March 28, 2012
    Copyright © 2012 American Chemical Society
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    Abstract

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    Studies addressing health effects of manganese (Mn) excess or deficiency during prenatal development are hampered by a lack of biomarkers that can reconstruct fetal exposure. We propose a method using the neonatal line, a histological feature in deciduous teeth, to identify regions of mantle dentine formed at different prenatal periods. Micromeasurements of Mn in these regions may be used to reconstruct exposure at specific times in fetal development. To test our hypothesis, we recruited pregnant women before 20 weeks gestation from a cohort of farmworkers exposed to Mn-containing pesticides. We collected house floor dust samples and mother’s blood during the second trimester; umbilical cord blood at birth; and shed deciduous incisors when the child was ∼7 years of age. Mn levels in mantle dentine formed during the second trimester (as 55Mn:43Ca area under curve) were significantly associated with floor dust Mn loading (rspearman = 0.40; p = 0.0005; n = 72). Furthermore, 55Mn:43Ca in sampling points immediately adjacent the neonatal line were significantly associated to Mn concentrations in cord blood (rspearman = 0.70; p = 0.003; n = 16). Our results support that Mn levels in mantle dentine are useful in discerning perinatal Mn exposure, offering a potentially important biomarker for the study of health effects due to environmental Mn exposure.

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    Supporting Information

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    Typical operating conditions for laser ablation analysis (Table S1); Schematic of tooth development (Figure S1); Reproducibility of 55Mn:43Ca measurements in dentine (Figure S2); Comparison of LA-ICP-MS Mn measurements in dentine with in-solution ICP-MS analysis (Figure S3); Direct measurement of enamel growth rate (Figure S4). This material is available free of charge via the Internet at http://pubs.acs.org.

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    Cite this: Environ. Sci. Technol. 2012, 46, 9, 5118–5125
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    https://doi.org/10.1021/es203569f
    Published March 28, 2012
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