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The Kondrat’eva Reaction in Flow: Direct Access to Annulated Pyridines

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Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada, and F. Hoffmann-La Roche AG, pRED, Pharma Research & Early Development, Small Molecule Research, Medicinal Chemistry, Grenzacherstrasse 124, 4070 Basel, Switzerland
‡F. Hoffmann-La Roche AG.
†Simon Fraser University.
Cite this: Org. Lett. 2013, 15, 14, 3550–3553
Publication Date (Web):June 27, 2013
https://doi.org/10.1021/ol4013525
Copyright © 2013 American Chemical Society

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    Abstract

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    A continuous flow inverse-electron-demand Kondrat’eva reaction has been developed that provides direct access to cycloalka[c]pyridines from unactivated oxazoles and cycloalkenes. Annulated pyridines obtained by this one-step process are valuable scaffolds for medicinal chemistry.

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