Protein Motion in Catalysis
The Special Issue on Protein Motion in Catalysis, guest-edited by two of the leaders in this very active area of research, Judith Klinman and Sharon Hammes-Schiffer, includes Accounts by authorities in the field, discussing their work on the role of protein motions, or dynamics, on the ability of enzymes to cause remarkable accelerations of the reactions necessary for life.
Experimental enzymology, directed evolution, crystallography, protein design, and molecular dynamics calculations provide a definitive view of our understanding of how the dynamic motions of the protein, including loop motions and coupling of remote vibrations to active site dynamics, influence the rates of enzyme-catalyzed reactions.
Cover design by authors, Sílvia Osuna, Gonzalo Jiménez-Osés, Elizabeth L. Noey, and K. N. Houk; layout by Jeff Ward
Editorial
Emerging Concepts about the Role of Protein Motion in Enzyme Catalysis
Sharon Hammes-Schiffer (Guest Editor) and Judith Klinman (Guest Editor)
DOI: 10.1021/acs.accounts.5b00113
Articles
Enzyme Dynamics from NMR Spectroscopy
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Role of Dynamics in Enzyme Catalysis: Substantial versus Semantic Controversies
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Dynamically Achieved Active Site Precision in Enzyme Catalysis
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Role of Substrate Dynamics in Protein Prenylation Reactions
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The Importance of Ensemble Averaging in Enzyme Kinetics
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Perspectives on Electrostatics and Conformational Motions in Enzyme Catalysis
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Keep on Moving: Discovering and Perturbing the Conformational Dynamics of Enzymes
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The Dynamical Nature of Enzymatic Catalysis
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Charge Transfer in Dynamical Biosystems, or The Treachery of (Static) Images
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ACS Editors' Choice® is a collection designed to feature scientific articles of broad public interest. Read the latest articles
Markov State Models Provide Insights into Dynamic Modulation of Protein Function
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ACS Editors' Choice® is a collection designed to feature scientific articles of broad public interest. Read the latest articles
