Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect
ACS Publications. Most Trusted. Most Cited. Most Read
Novel Double-Layer Dissolving Microneedles for Transmucosal Sequential Delivery of Multiple Drugs in the Treatment of Oral Mucosa Diseases

OR SEARCH CITATIONS

My Activity
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Appl. Mater. Interfaces 2023, 15, 11, 13892-13906
    Biological and Medical Applications of Materials and Interfaces

    Novel Double-Layer Dissolving Microneedles for Transmucosal Sequential Delivery of Multiple Drugs in the Treatment of Oral Mucosa Diseases
    Click to copy article linkArticle link copied!

    • Yang Meng
      Yang Meng
      State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
      More by Yang Meng
      Orcidhttps://orcid.org/0000-0001-9662-3699
    • Xin Jiao Li
      Xin Jiao Li
      School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, P.R. China
      More by Xin Jiao Li
    • Yao Li
      Yao Li
      School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, P.R. China
      More by Yao Li
    • Tian Yu Zhang
      Tian Yu Zhang
      State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
      More by Tian Yu Zhang
    • Dan Liu
      Dan Liu
      State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
      More by Dan Liu
    • Yu Qi Wu
      Yu Qi Wu
      State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
      More by Yu Qi Wu
    • Fei Fei Hou
      Fei Fei Hou
      State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
      More by Fei Fei Hou
    • Lu Ye
      Lu Ye
      State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
      More by Lu Ye
    • Chuan Ji Wu
      Chuan Ji Wu
      State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
      More by Chuan Ji Wu
    • Xiao Dong Feng
      Xiao Dong Feng
      State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
      More by Xiao Dong Feng
    • Xiao Jie Ju*
      Xiao Jie Ju
      School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, P.R. China
      State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan 610065, P.R. China
      *Email: [email protected]
      More by Xiao Jie Ju
      Orcidhttps://orcid.org/0000-0003-1086-338X
    • Lu Jiang*
      Lu Jiang
      State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
      *Email: [email protected]
      More by Lu Jiang
    Other Access OptionsSupporting Information (1)

    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2023, 15, 11, 13892–13906
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.2c19913
    Published March 9, 2023
    Copyright © 2023 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    The development of transmucosal drug delivery systems is a practical requirement in oral clinical practice, and controlled sequential delivery of multiple drugs is usually required. On the basis of the previous successful construction of monolayer microneedles (MNs) for transmucosal drug delivery, we designed transmucosal double-layer sequential dissolving MNs using hyaluronic acid methacryloyl (HAMA), hyaluronic acid (HA), and polyvinyl pyrrolidone (PVP). MNs have the advantages of small size, easy operation, good strength, rapid dissolution, and one-time delivery of two drugs. Morphological test results showed that the HAMA-HA-PVP MNs were small and intact in structure. The mechanical strength and mucosal insertion test results indicated the HAMA-HA-PVP MNs had appropriate strength and could penetrate the mucosal cuticle quickly to achieve transmucosal drug delivery. The in vitro and in vivo experiment results of the double-layer fluorescent dyes simulating drug release revealed that MNs had good solubility and achieved stratified release of the model drugs. The results of the in vivo and in vitro biosafety tests also indicated that the HAMA-HA-PVP MNs were biosafe materials. The therapeutic effect of drug-loaded HAMA-HA-PVP MNs in the rat oral mucosal ulcer model demonstrated that these novel HAMA-HA-PVP MNs quickly penetrated the mucosa, dissolved and effectively released the drug, and achieved sequential drug delivery. Compared to monolayer MNs, these HAMA-HA-PVP MNs can be used as double-layer drug reservoirs for controlled release, effectively releasing the drug in the MN stratification by dissolution in the presence of moisture. The need for secondary or multiple injections can be avoided, thus improving patient compliance. This drug delivery system can serve as an efficient, multipermeable, mucosal, and needle-free alternative for biomedical applications.

    Copyright © 2023 American Chemical Society

    Subjects

    what are subjects

    Keywords

    what are keywords

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Supporting Information

    Click to copy section linkSection link copied!

    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsami.2c19913.

    • Swelling of HAMA MNs: cross-linked time (a) 0 min, (b) 5 min, and (c) 20 min (Figure S1); microscopic images of HA-HAMA-PVP MNs that punctured and were kept in rabbit oral mucosa for different time periods (Figure S2); local drug delivery in the oral mucosa of rats after applying the dyed HAMA-HA-PVP MNs and the dye patches for 5 and 120 min (Figure S3); estimation of drug loading of HAMA-HA-PVP MNs (Figure S4); CCK-8 assay for quantitative evaluation of HOK cell viability after treatment with the three components of the HAMA-HA-PVP MNs for different concentrations at 24, 48, and 72 h (Figure S5); live/dead assay for HOK cells treated with HAMA-HA-PVP MNs (at 72 h); the control was not treated (Figure S6); and facial wiping behavior (facial wiping with one or both forelimbs) (Figure S7) (PDF)

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    Click to copy section linkSection link copied!

    This article is cited by 2 publications.

    1. Yunli Xia, Ke Xu, Maoqi Luo, Zeya Li, Siwuxie He, Tao Gong, Zhirong Zhang, Li Deng. A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia. ACS Applied Bio Materials 2024, 7 (2) , 1229-1239. https://doi.org/10.1021/acsabm.3c01128
    2. Puxuan Zhao, Zhiming Li, Zhixin Ling, Yanting Zheng, Hao Chang. Efficient Loading and Sustained Delivery of Methotrexate Using a Tip-Swellable Microneedle Array Patch for Psoriasis Treatment. ACS Biomaterials Science & Engineering 2024, 10 (2) , 921-931. https://doi.org/10.1021/acsbiomaterials.3c01810
    Download PDF
    Go to ACS Applied Materials & Interfaces
    Get e-Alerts
    Get e-Alerts

    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2023, 15, 11, 13892–13906
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.2c19913
    Published March 9, 2023
    Copyright © 2023 American Chemical Society
    Request reuse permissions

    Article Views

    3358

    Altmetric

    -

    Citations

    2
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.