Photocatalysis in the Life Science IndustryClick to copy article linkArticle link copied!
- Lisa Candish*Lisa Candish*Email: [email protected]Drug Discovery Sciences, Pharmaceuticals, Bayer AG, 42113 Wuppertal, GermanyMore by Lisa Candish
- Karl D. Collins*Karl D. Collins*Email: [email protected]Bayer Foundation, Public Affairs, Science and Sustainability, Bayer AG, 51368 Leverkusen, GermanyMore by Karl D. Collins
- Gemma C. CookGemma C. CookDiscovery High-Throughput Chemistry, Medicinal Science and Technology, GlaxoSmithKline, Stevenage SG1 2NY, U.K.More by Gemma C. Cook
- James J. DouglasJames J. DouglasEarly Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, U.K.More by James J. Douglas
- Adrián Gómez-SuárezAdrián Gómez-SuárezOrganic Chemistry, Bergische Universität Wuppertal, 42119 Wuppertal, GermanyMore by Adrián Gómez-Suárez
- Anais JolitAnais JolitMedicinal Chemistry Department, Neuroscience Discovery Research, AbbVie Deutschland GmbH & Co. KG, 67061 Ludwigshafen, GermanyMore by Anais Jolit
- Sebastian KeessSebastian KeessMedicinal Chemistry Department, Neuroscience Discovery Research, AbbVie Deutschland GmbH & Co. KG, 67061 Ludwigshafen, GermanyMore by Sebastian Keess
Abstract
![Abstract Image](/cms/10.1021/acs.chemrev.1c00416/asset/images/medium/cr1c00416_0177.gif)
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science industry require access to mild and robust synthetic methodologies to systematically modify chemical structures, explore novel chemical space, and enable efficient synthesis. In this context, photocatalysis has emerged as a powerful technology for the synthesis of complex and often highly functionalized molecules. This Review aims to summarize the published contributions to the field from the life science industry, including research from industrial-academic partnerships. An overview of the synthetic methodologies developed and strategic applications in chemical synthesis, including peptide functionalization, isotope labeling, and both DNA-encoded and traditional library synthesis, is provided, along with a summary of the state-of-the-art in photoreactor technology and the effective upscaling of photocatalytic reactions.
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