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Protein Nanocages for Delivery and Release of Luminescent Ruthenium(II) Polypyridyl Complexes

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    Protein Nanocages for Delivery and Release of Luminescent Ruthenium(II) Polypyridyl Complexes
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    † Department of Polymer Science & Engineering, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China
    ‡ Lab of Advanced Functional Materials, School of Environmental Science, Nanjing Xiaozhuang University, Nanjing 210013, P. R. China
    *E-mail: [email protected]
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    ACS Applied Materials & Interfaces

    Cite this: ACS Appl. Mater. Interfaces 2016, 8, 35, 22756–22761
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    https://doi.org/10.1021/acsami.6b07038
    Published August 22, 2016
    Copyright © 2016 American Chemical Society
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    Abstract

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    In this report, noncovalent encapsulation of hydrophobic ruthenium(II) polyridyl complexes, Ru(bpy)2dppz2+ and Ru(phen)2dppz2+, into apoferritin cavity was achieved with high loading contents by effective prevention of Ru complex-induced protein aggregation, without disruption of protein native architecture. The Ru-loaded luminescent nanocomposites have demonstrated improved water solubility, easy manipulation, reduced cytotoxicity, and enhanced cellular uptake as compared to the nontreated Ru complexes.

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    Supporting Information

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsami.6b07038.

    • Further experimental details, metal content analysis, measurements of UV/vis absorption and luminescence spectra, TEM analysis, DLS and ζ-potential measurement, CD measurement, Ru release kinetics, MTT assay, fluorescence confocal imaging (PDF)

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    Cite this: ACS Appl. Mater. Interfaces 2016, 8, 35, 22756–22761
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsami.6b07038
    Published August 22, 2016
    Copyright © 2016 American Chemical Society
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