Protein Nanocages for Delivery and Release of Luminescent Ruthenium(II) Polypyridyl ComplexesClick to copy article linkArticle link copied!
Abstract
![Abstract Image](/cms/10.1021/acsami.6b07038/asset/images/medium/am-2016-070389_0006.gif)
In this report, noncovalent encapsulation of hydrophobic ruthenium(II) polyridyl complexes, Ru(bpy)2dppz2+ and Ru(phen)2dppz2+, into apoferritin cavity was achieved with high loading contents by effective prevention of Ru complex-induced protein aggregation, without disruption of protein native architecture. The Ru-loaded luminescent nanocomposites have demonstrated improved water solubility, easy manipulation, reduced cytotoxicity, and enhanced cellular uptake as compared to the nontreated Ru complexes.
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(15)
, 8825-9014. https://doi.org/10.1021/acs.chemrev.3c00629
- Clémence Queffélec, Palas Baran Pati, Yann Pellegrin. Fifty Shades of Phenanthroline: Synthesis Strategies to Functionalize 1,10-Phenanthroline in All Positions. Chemical Reviews 2024, 124
(11)
, 6700-6902. https://doi.org/10.1021/acs.chemrev.3c00543
- Kazuyuki Nobusawa, Huan-Wen Han, Fumie Takei, Ting-Chieh Chu, Noriyasu Hashida, Ichiro Yamashita. Electrochemical Impedimetric Real-Time Polymerase Chain Reactions Using Anomalous Charge Transfer Enhancement. Analytical Chemistry 2022, 94
(22)
, 7747-7751. https://doi.org/10.1021/acs.analchem.2c01659
- Xiaoxuan Wei, Luyang Ji, Jinlei Peng, Ke Du, Fude Feng. Noncovalent Engineering of Apoferritin with a PEGylated [FeFe] Hydrogenase Mimic for In Situ Polymerization. ACS Applied Bio Materials 2022, 5
(4)
, 1756-1765. https://doi.org/10.1021/acsabm.2c00124
- HuanWen Han, Kazuyuki Nobusawa, Ichiro Yamashita. Anomalous Enhancement of Electrochemical Charge Transfer by a Ru Complex Ion Intercalator. Analytical Chemistry 2022, 94
(2)
, 571-576. https://doi.org/10.1021/acs.analchem.1c03681
- Kai Xiong, Ying Zhou, Johannes Karges, Kejie Du, Jinchao Shen, Mingwei Lin, Fangmian Wei, Junfeng Kou, Yu Chen, Liangnian Ji, Hui Chao. Autophagy-Dependent Apoptosis Induced by Apoferritin–Cu(II) Nanoparticles in Multidrug-Resistant Colon Cancer Cells. ACS Applied Materials & Interfaces 2021, 13
(33)
, 38959-38968. https://doi.org/10.1021/acsami.1c07223
- Xiantao Hu, Weijian Chen, Shuyi Li, Jian Sun, Ke Du, Qiuyu Xia, Fude Feng. Diiron Dithiolate Complex Induced Helical Structure of Histone and Application in Photochemical Hydrogen Generation. ACS Applied Materials & Interfaces 2019, 11
(22)
, 19691-19699. https://doi.org/10.1021/acsami.9b01866
- Kelong Fan, Xiaohua Jia, Meng Zhou, Kun Wang, João Conde, Jiuyang He, Jie Tian, Xiyun Yan. Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma. ACS Nano 2018, 12
(5)
, 4105-4115. https://doi.org/10.1021/acsnano.7b06969
- Bin Du, Shaona Jia, Qinghui Wang, Xiaoyu Ding, Ying Liu, Hanchun Yao, Jie Zhou. A Self-Targeting, Dual ROS/pH-Responsive Apoferritin Nanocage for Spatiotemporally Controlled Drug Delivery to Breast Cancer. Biomacromolecules 2018, 19
(3)
, 1026-1036. https://doi.org/10.1021/acs.biomac.8b00012
- Weijian Chen, Yajie Zhang, Xiao Li, Hong Chen, Jian Sun, and Fude Feng . H2S Activated Drug Release from Protein Cages. ACS Applied Materials & Interfaces 2017, 9
(39)
, 33571-33575. https://doi.org/10.1021/acsami.7b12524
- Xiao Li, Yajie Zhang, Jian Sun, Weijian Chen, Xuewei Wang, Fenli Shao, Yuyu Zhu, Fude Feng, and Yang Sun . Protein Nanocage-Based Photo-Controlled Nitric Oxide Releasing Platform. ACS Applied Materials & Interfaces 2017, 9
(23)
, 19519-19524. https://doi.org/10.1021/acsami.7b03962
- Rosanna Lucignano, Gennaro Sanità, Emanuela Esposito, Irene Russo Krauss, Anna Maria D'Ursi, Michela Buonocore, Delia Picone. Human ferritin nanocarriers for drug-delivery: A molecular view of the disassembly process. International Journal of Biological Macromolecules 2024, 277 , 134373. https://doi.org/10.1016/j.ijbiomac.2024.134373
- Kai Xiong, Xinlin Lin, Junfeng Kou, Fangmian Wei, Jinchao Shen, Yu Chen, Liangnian Ji, Hui Chao. Apoferritin‐Cu(II) Nanoparticles Induce Oncosis in Multidrug‐Resistant Colon Cancer Cells. Advanced Healthcare Materials 2024, 13
(5)
https://doi.org/10.1002/adhm.202302564
- Huanwen Han, Kazuyuki Nobusawa, Fumie Takei, Ting-Chieh Chu, Noriyasu Hashida, Ichiro Yamashita. Ru Complex Ion Induces Anomalous Enhancement of Electrochemical Charge Transfer. 2023https://doi.org/10.5772/intechopen.110360
- Lucie Haye, Nour Fayad, Richard C. Knighton, Antoine Combes, Olivier Jeannin, Andrey Klymchenko, Thibault Gallavardin, Niko Hildebrandt, Loïc J. Charbonnière, Andreas Reisch. NIR FRET Luminescence in Rhenium Complex and Dye Co‐Loaded Polymer Nanoparticles. Advanced Materials Technologies 2023, 8
(22)
https://doi.org/10.1002/admt.202301016
- Maomao He, Zongwei Zhang, Ziyue Jiao, Meiyu Yan, Pengcheng Miao, Zhiyong Wei, Xuefei Leng, Yang Li, Jiangli Fan, Wen Sun, Xiaojun Peng. Redox-responsive phenyl-functionalized polylactide micelles for enhancing Ru complexes delivery and phototherapy. Chinese Chemical Letters 2023, 34
(3)
, 107574. https://doi.org/10.1016/j.cclet.2022.05.088
- Rosanna Lucignano, Ilaria Stanzione, Giarita Ferraro, Rocco Di Girolamo, Carolina Cané, Angela Di Somma, Angela Duilio, Antonello Merlino, Delia Picone. A new and efficient procedure to load bioactive molecules within the human heavy-chain ferritin nanocage. Frontiers in Molecular Biosciences 2023, 10 https://doi.org/10.3389/fmolb.2023.1008985
- Fabian Heide, Jörg Stetefeld. A Structural Analysis of Proteinaceous Nanotube Cavities and Their Applications in Nanotechnology. Nanomaterials 2022, 12
(22)
, 4080. https://doi.org/10.3390/nano12224080
- Rezvan Yazdian-Robati, Payam Bayat, Sina Dehestani, Maryam Hashemi, Seyed Mohammad Taghdisi, Khalil Abnous. Smart delivery of epirubicin to cancer cells using aptamer-modified ferritin nanoparticles. Journal of Drug Targeting 2022, 30
(5)
, 567-576. https://doi.org/10.1080/1061186X.2022.2025600
- Marcia V. S. Lima, Rafael C. Marchi, Carolina R. Cardoso, Nathan P. Cook, Wallance M. Pazin, Flavio V. C. Kock, Tiago Venâncio, Angel A. Martí, Rose M. Carlos. Bidentate Coordination of 2‐Aminopyridine (2Apy) in
cis
‐[Ru(phen)
2
(2Apy)]
2+
Aiming at Photobiological Studies. European Journal of Inorganic Chemistry 2022, 2022
(11)
https://doi.org/10.1002/ejic.202101015
- Luca Conti, Silvia Ciambellotti, Gina Elena Giacomazzo, Veronica Ghini, Lucrezia Cosottini, Elisa Puliti, Mirko Severi, Emiliano Fratini, Francesca Cencetti, Paola Bruni, Barbara Valtancoli, Claudia Giorgi, Paola Turano. Ferritin nanocomposites for the selective delivery of photosensitizing ruthenium-polypyridyl compounds to cancer cells. Inorganic Chemistry Frontiers 2022, 9
(6)
, 1070-1081. https://doi.org/10.1039/D1QI01268A
- A. Byrne, David Cullinane, Karmel S. Gkika, Christopher S. Burke, Tia E. Keyes. Luminescent Metal Complexes in Bioimaging. 2022, 1073-1107. https://doi.org/10.1007/978-3-030-63713-2_37
- Tanvi Sushil Kaku, Sierin Lim. Protein nanoparticles in molecular, cellular, and tissue imaging. WIREs Nanomedicine and Nanobiotechnology 2021, 13
(5)
https://doi.org/10.1002/wnan.1714
- Baoli Zhang, Guoheng Tang, Jiuyang He, Xiyun Yan, Kelong Fan. Ferritin nanocage: A promising and designable multi-module platform for constructing dynamic nanoassembly-based drug nanocarrier. Advanced Drug Delivery Reviews 2021, 176 , 113892. https://doi.org/10.1016/j.addr.2021.113892
- Jinchao Shen, Thomas W. Rees, Liangnian Ji, Hui Chao. Recent advances in ruthenium(II) and iridium(III) complexes containing nanosystems for cancer treatment and bioimaging. Coordination Chemistry Reviews 2021, 443 , 214016. https://doi.org/10.1016/j.ccr.2021.214016
- Yi Gou, GuoJin Huang, Jinlong Li, Feng Yang, Hong Liang. Versatile delivery systems for non-platinum metal-based anticancer therapeutic agents. Coordination Chemistry Reviews 2021, 441 , 213975. https://doi.org/10.1016/j.ccr.2021.213975
- Hongdong Shi, Jingxue Lou, Simin Lin, Yi Wang, Yatao Hu, Pingyu Zhang, Yangzhong Liu, Qianling Zhang. Diatom-like silica–protein nanocomposites for sustained drug delivery of ruthenium polypyridyl complexes. Journal of Inorganic Biochemistry 2021, 221 , 111489. https://doi.org/10.1016/j.jinorgbio.2021.111489
- Tingxizi Liang, Benhua Zhang, Zejing Xing, Yuxiang Dong, Hongmei Xu, Xueqin Chen, Liping Jiang, Jun‐Jie Zhu, Qianhao Min. Adapting and Remolding: Orchestrating Tumor Microenvironment Normalization with Photodynamic Therapy by Size Transformable Nanoframeworks. Angewandte Chemie 2021, 133
(20)
, 11565-11574. https://doi.org/10.1002/ange.202102180
- Tingxizi Liang, Benhua Zhang, Zejing Xing, Yuxiang Dong, Hongmei Xu, Xueqin Chen, Liping Jiang, Jun‐Jie Zhu, Qianhao Min. Adapting and Remolding: Orchestrating Tumor Microenvironment Normalization with Photodynamic Therapy by Size Transformable Nanoframeworks. Angewandte Chemie International Edition 2021, 60
(20)
, 11464-11473. https://doi.org/10.1002/anie.202102180
- Xiaoli Xia, Daobin Zhang, Congbin Fan, Shouzhi Pu. Naked‐eye detection of Cu (II) and Fe (III) based on a Schiff Base Ruthenium complex with nicotinohydrazide. Applied Organometallic Chemistry 2020, 34
(10)
https://doi.org/10.1002/aoc.5841
- Chenxi Zhang, Xiaorong Zhang, Guanghua Zhao. Ferritin Nanocage: A Versatile Nanocarrier Utilized in the Field of Food, Nutrition, and Medicine. Nanomaterials 2020, 10
(9)
, 1894. https://doi.org/10.3390/nano10091894
- Dongmei Wang, Li Chen, Mingyue Wang, Meiying Cui, Lili Huang, Wei Xia, Xingang Guan. Delivering Proapoptotic Peptide by HSP Nanocage for Cancer Therapy. Macromolecular Chemistry and Physics 2020, 221
(12)
https://doi.org/10.1002/macp.202000003
- Gabriella Pinto, Mariavittoria D'Acierno, Anna Illiano, Ganna Petruk, Giarita Ferraro, Antonello Merlino, Daria Maria Monti, Jasminka Godovac-Zimmermann, Angela Amoresano. Label-free quantitative proteomics of the MCF-7 cellular response to a ferritin–metallodrug complex. Molecular Omics 2020, 16
(2)
, 165-173. https://doi.org/10.1039/C9MO00158A
- Rupali Reddy Pasula, Ambili Kuniyil, Sierin Lim. Molecular Entrapment in Thermophilic Ferritin for Nanoformulation in Photodynamic Therapy. Advanced Therapeutics 2020, 3
(3)
https://doi.org/10.1002/adtp.201900172
- Weijian Chen, Xuetong Cai, Luyang Ji, Xiao Li, Xuewei Wang, Xiaoran Zhang, Yajing Gao, Fude Feng. A photosynthesis-inspired supramolecular system: caging photosensitizer and photocatalyst in apoferritin. Photosynthesis Research 2019, 142
(2)
, 169-180. https://doi.org/10.1007/s11120-019-00671-4
- Olga Mazuryk, Przemysław Gajda-Morszewski, Małgorzata Brindell. Versatile Impact of Serum Proteins on Ruthenium(II) Polypyridyl Complexes Properties - Opportunities and Obstacles. Current Protein & Peptide Science 2019, 20
(11)
, 1052-1059. https://doi.org/10.2174/1389203720666190513090851
- Dara Maria Monti, Giarita Ferraro, Antonello Merlino. Ferritin-based anticancer metallodrug delivery: Crystallographic, analytical and cytotoxicity studies. Nanomedicine: Nanotechnology, Biology and Medicine 2019, 20 , 101997. https://doi.org/10.1016/j.nano.2019.04.001
- Yingjie Yu, Quan Xu, Shasha He, Hejian Xiong, Qingfei Zhang, Weiguo Xu, Vincent Ricotta, Lei Bai, Qi Zhang, Zhiqiang Yu, Jianxun Ding, Haihua Xiao, Dongfang Zhou. Recent advances in delivery of photosensitive metal-based drugs. Coordination Chemistry Reviews 2019, 387 , 154-179. https://doi.org/10.1016/j.ccr.2019.01.020
- Ganna Petruk, Daria Maria Monti, Giarita Ferraro, Andrea Pica, Luigi D'Elia, Francesca Pane, Angela Amoresano, Julien Furrer, Konrad Kowalski, Antonello Merlino. Encapsulation of the Dinuclear Trithiolato‐Bridged Arene Ruthenium Complex Diruthenium‐1 in an Apoferritin Nanocage: Structure and Cytotoxicity. ChemMedChem 2019, 14
(5)
, 594-602. https://doi.org/10.1002/cmdc.201800805
- Weijian Chen, Shuyi Li, Xiao Li, Chi Zhang, Xiantao Hu, Fan Zhu, Guosong Shen, Fude Feng. Iron sulfur clusters in protein nanocages for photocatalytic hydrogen generation in acidic aqueous solutions. Chemical Science 2019, 10
(7)
, 2179-2185. https://doi.org/10.1039/C8SC05293J
- Jiajing Diao, Feng Bai, Ying Wang, Qianqian Han, Xi Xu, Hongmei Zhang, Qiang Luo, Yanqing Wang. Engineering of pectin-dopamine nano-conjugates for carrying ruthenium complex: A potential tool for biomedical applications. Journal of Inorganic Biochemistry 2019, 191 , 135-142. https://doi.org/10.1016/j.jinorgbio.2018.11.016
- Yupeng Wang, Lesan Yan, Shasha He, Dongfang Zhou, Yanxiang Cheng, Xuesi Chen, Xiabin Jing, Yubin Huang. A Versatile Method to Prepare Protein Nanoclusters for Drug Delivery. Macromolecular Bioscience 2018, 18
(2)
https://doi.org/10.1002/mabi.201700282
- Bo Wei, Meng Yue Guo, Yi Ming Lu, Peng Peng Sun, Gao Wen Yang, Qiao Yun Li. Synthesis of a Ruthenium(II) Compound based on 5‐(2‐Pyrimidyl)‐1H‐tetrazole for Photodynamic Therapy. Zeitschrift für anorganische und allgemeine Chemie 2018, 644
(1)
, 6-11. https://doi.org/10.1002/zaac.201700343
- Kelong Fan, Xiyun Yan. Bioengineered Ferritin Nanoprobes for Cancer Theranostics. 2018, 143-175. https://doi.org/10.1016/B978-0-12-813339-2.00006-2
- Meenakshi N. Shinde, Soniya S. Rao, Shridhar P. Gejji, Anupa A. Kumbhar. Distinct photophysical behaviour and transport of cell-impermeable [Ru(bpy)
2
dppz]
2+
in live cells using cucurbit[7]uril as a delivery system. Dalton Transactions 2018, 47
(11)
, 3857-3863. https://doi.org/10.1039/C7DT04230B
- Jenny Ling-Yu Chen, Yuan-Chun Tsai, Ming-Hsien Tsai, Shin-Yu Lee, Ming-Feng Wei, Sung-Hsin Kuo, Ming-Jium Shieh. Prominin-1-Specific Binding Peptide-Modified Apoferritin Nanoparticle Carrying Irinotecan as a Novel Radiosensitizer for Colorectal Cancer Stem-Like Cells. Particle & Particle Systems Characterization 2017, 34
(5)
, 1600424. https://doi.org/10.1002/ppsc.201600424
- Parham Sahandi Zangabad, Mahdi Karimi, Fatemeh Mehdizadeh, Hedieh Malekzad, Alireza Ghasemi, Sajad Bahrami, Hossein Zare, Mohsen Moghoofei, Amin Hekmatmanesh, Michael R. Hamblin. Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger. Nanoscale 2017, 9
(4)
, 1356-1392. https://doi.org/10.1039/C6NR07315H
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