Multicomponent Synthesis of Imidazo[1,2-a]pyridines: Aerobic Oxidative Formation of C–N and C–S Bonds by Flavin–Iodine-Coupled OrganocatalysisClick to copy article linkArticle link copied!
- Hayaki OkaiHayaki OkaiDepartment of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, JapanMore by Hayaki Okai
- Kazumasa TanimotoKazumasa TanimotoDepartment of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, JapanMore by Kazumasa Tanimoto
- Ryoma OhkadoRyoma OhkadoDepartment of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, JapanMore by Ryoma Ohkado
- Hiroki Iida*Hiroki Iida*Email: [email protected]Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, JapanMore by Hiroki Iida
Abstract
![Abstract Image](/cms/10.1021/acs.orglett.0c02929/asset/images/medium/ol0c02929_0009.gif)
Herein, we report an aerobic oxidative C–N bond-forming process that enables the facile synthesis of imidazo[1,2-a]pyridines and takes advantage of a coupled organocatalytic system that uses flavin and iodine. Furthermore, the dual catalytic system can be applied to the one-pot, three-step synthesis of 3-thioimidazo[1,2-a]pyridines from aminopyridines, ketones, and thiols.
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